treatment of colchicine-resistant familial mediterranean fever with anakinra

conclusions this case showed the effect of additional anakinra on children with fmf who were colchicine resistant. case presentation herein was reported a colchicine non-responsive patient with accurate diagnosis and early treatment of fmf. she had presented with recurrent and persistent acute abdominal pain attacks and several abdominal surgeries. addition of recombinant interleukin-1 receptor antagonist (anakinra) to colchicine was effective to decrease the number and severity of abdominal pain in the patient. introduction familial mediterranean fever (fmf) is an auto-inflammatory disease presenting with periodic fever and various clinical manifestations. almost 10% of the patients with fmf do not respond to colchicine therapy.